Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Akathisia
ADR ID BADD_A00129
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.002      Akathisia
19      Psychiatric disorders
19.06      Anxiety disorders and symptoms
19.06.02      Anxiety symptoms
19.06.02.006      Akathisia
Description A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs. [CTCAE] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions. [MeSH]
MedDRA Code 10001540
MeSH ID D011595
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acathesia | Akathisia | Motor restlessness | Motor unrest compulsive | Akathisia aggravated | Acathisia | Psychomotor Agitation | Restlessness | Psychomotor Hyperactivity | Hyperactivity, Psychomotor | Psychomotor Restlessness | Restlessness, Psychomotor | Agitation, Psychomotor | Excitement, Psychomotor | Psychomotor Excitement
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
D(1A) dopamine receptorP21728T22118
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00879Fentanyl--
BADD_D00880Fentanyl citrate--
BADD_D00932Fluoxetine0.001407%
BADD_D00933Fluoxetine hydrochloride--
BADD_D00935Fluphenazine--
BADD_D00936Fluphenazine decanoate--
BADD_D00937Fluphenazine hydrochloride--
BADD_D00950Fluvoxamine--
BADD_D00951Fluvoxamine maleate--
BADD_D00970Fosphenytoin--
BADD_D00971Fosphenytoin sodium--
BADD_D00981Gabapentin0.000254%
BADD_D00989Gadolinium--
BADD_D01051Halobetasol--
BADD_D01054Haloperidol0.009096%
BADD_D01055Haloperidol decanoate--
BADD_D01056Haloperidol lactate--
BADD_D01102Hydroxybutanoic acid--
BADD_D01132Idursulfase--
BADD_D01134Iloperidone0.000602%
BADD_D01196Irinotecan hydrochloride--
BADD_D01202Isocarboxazid--
BADD_D01243Lamotrigine0.000773%
BADD_D01265Levetiracetam--
BADD_D01303Lithium carbonate0.001227%
BADD_D01318Lorazepam0.000201%
BADD_D01326Loxapine--
BADD_D01327Loxapine succinate--
BADD_D01330Lurasidone0.010351%
BADD_D01331Lurasidone hydrochloride--
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